The shooting on Skid Row was reported just before 2 p.m. in the area near 400 E. 5th Street. Authorities said multiple people were shot.
The suspect is described as a man in his mid-20s wearing a black jacket, black jeans, and black shoes. He was last seen in a dark charcoal grey Saturn driving on 5th Street from San Julian.
Authorities are actively investigating what exactly led up to the shooting.